The diagnosis of DCMi rests on complex methods including histological, immunhistological, and molecular biological techniques. To provide standardized biopsy-based diagnostics for all clinical projects we have installed the project Z1 as a "core facility". Project Z1 is closely interconnected with the second core project Z2. First, Z2 is responsible for central data management, sample documentation and logistics, and quality control. Second, Z2 is responsible for the acquisition of population-wide epidemiological data on DCMi with its various subtypes. In addition to established diagnostic procedures Z1 and Z2 have the important goal to derive novel prognostic parameters from both cross-sectional and longitudinal studies. These data shall provide a basis for early and causal therapies directed at specific pathomechanisms. Project Z3 is another important core facility which provides state-of-the-art animal experimental facilities for the standardized hemodynamic and functional characterization of all animal models employed by SFB research groups.
The establishment of these three core facilities with appropriate apparative equipment was of key importance to provide very high methodological standards for the whole SFB/TR 19. Results are thus directly comparable between the different projects which is one major prerequisite for the development of diagnostic and therapeutic guidelines. |
